Related Experiment Video
Updated: Mar 26, 2026

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
Published on: June 7, 2011
Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology
Conrad P Hodgkinson1, Akshay Bareja1, José A Gomez1
1From the Department of Medicine, Mandel Center for Hypertension Research and Duke Cardiovascular Research Center, Duke University Medical Center, Durham, NC.
Abstract:
In the past decade, substantial evidence supports the paradigm that stem cells exert their reparative and regenerative effects, in large part, through the release of biologically active molecules acting in a paracrine fashion on resident cells. The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.
Related Concept Videos
Paracrine Signaling
Paracrine Signaling
Regulation of Angiogenesis and Blood Supply
Mechanism of Angiogenesis
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...

