Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Psycho-oncology in India.

Journal of cancer policy·2025

Same author

Correlation of the Geriatric Assessment with Overall Survival in Older Patients with Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023

Same author

Experience with Prognosis Communication in Parents of Children Having Advanced Cancer.

Indian journal of pediatrics·2022

Same author

A prospective study of telephonic contact and subsequent physical follow-up of radically treated lung cancer patients.

Indian journal of cancer·2017

Same author

A retrospective audit of clinicopathological attributes and treatment outcomes of adolescent and young adult non-Hodgkin lymphomas from a tertiary care center.

Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology·2012

Same author

Histopathological audit of splenectomies received at a cancer hospital.

Indian journal of pathology & microbiology·2011

Same journal

News in oncology.

Indian journal of cancer·2026

Same journal

Unveiling the rare, interesting series of malignant mesenchymal tumors of the kidney in a regional cancer care institute in South India.

Indian journal of cancer·2026

Same journal

Why our unison matters: Head and neck cancer care providers.

Indian journal of cancer·2026

Same journal

District cancer control program: A white paper to optimize cancer care in rural India by developing a uniform, modular, and multi-tier system.

Indian journal of cancer·2026

Same journal

PI-RADS v2 score may be as a predictor of bone metastasis in prostate cancer.

Indian journal of cancer·2026

Same journal

Evaluation of sexual life quality and vaginal dose-volume relationship in female rectal cancer patients treated with pelvic radiotherapy.

Indian journal of cancer·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Developing a comprehensive cancer specific geriatric assessment tool.

S Rao, N Salins¹, J Deodhar

¹Department of Palliative Medicine, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Indian Journal of Cancer

|February 4, 2016

Summary

This summary is machine-generated.

This study developed a brief, cancer-specific geriatric assessment tool to identify medical, psychosocial, and functional issues in older adults with advanced cancer. The tool aims to improve geriatric palliative care for this growing population.

More Related Videos

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Related Experiment Videos

Last Updated: Mar 26, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

Area of Science:

Geriatric Medicine
Oncology
Palliative Care

Background:

Global population aging is a significant demographic trend, with a projected doubling of older adults by 2050.
Approximately 60% of elderly cancer patients may present with advanced-stage disease.
There is a critical need for specialized assessment tools for older adults with advanced cancer.

Purpose of the Study:

To develop a concise, cancer-specific comprehensive geriatric assessment tool.
To identify key medical, psychosocial, and functional issues in elderly patients with advanced cancer.
To support the development of geriatric palliative care services.

Main Methods:

A literature review identified validated tools for assessing geriatric needs in oncology.
The assessment incorporated domains such as socioeconomic status, physical symptoms, comorbidity, functional status, psychological status, social support, cognition, nutrition, and spiritual issues.
Validated instruments including the Kuppuswamy scale and Edmonton Symptom Assessment Scale were integrated, alongside the SAKK cancer-specific geriatric assessment tool.

Main Results:

The developed tool is brief, reliable, and valid for interviewer administration.
It addresses multiple domains crucial for comprehensive geriatric care in advanced cancer.
The tool was designed for integration into palliative care settings.

Conclusions:

The assessment tool was developed within the geriatric palliative care project at Tata Memorial Hospital, Mumbai.
Future plans include feasibility testing, needs assessment, and implementation of a comprehensive geriatric palliative care project.
The ultimate goal is to improve outcomes for older adults with advanced cancer through tailored palliative care.