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Updated: Mar 26, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Congenital Melanocytic Nevi
Maya Zayour1, Rossitza Lazova2
1Yale Dermatopathology Laboratory, Department of Dermatology, Yale University School of Medicine, 15 York Street, P.O. Box 208059, New Haven, CT 06520, USA.
Abstract:
This article reviews congenital melanocytic nevi (CMN), which are present at birth or appear shortly thereafter, and their main histologic features. Several histologic variants and histopathologic criteria that differentiate CMN from other nevi, such as atypical or dysplastic nevi, and from nevoid malignant melanoma, are discussed. Histologic pitfalls in the correct identification of lentiginous melanocytic hyperplasia, pagetoid scatter, and proliferative nodules in the context of CMN are discussed. The risk for development of malignant melanoma in association with a congenital melanocytic nevus and variable causes for changing mole are discussed.
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