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Related Experiment Video

Updated: Mar 26, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Desmoplastic Melanoma.

Klaus J Busam1

  • 1Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA; Weill Medical College of Cornell University, New York, NY, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary

Desmoplastic melanoma (DM) is a rare spindle cell melanoma variant often misdiagnosed due to indistinct clinical and histological features. While prone to local recurrence, it shows a lower risk of lymph node metastasis compared to conventional melanoma.

Keywords:
Desmoplastic melanomaDesmoplastic nevusMelanoma diagnosisPrognosisSarcomatoid skin tumors

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Desmoplastic melanoma (DM) is a spindle cell melanoma variant with abundant fibrous matrix.
  • Typically affects head and neck on sun-damaged skin in older individuals.
  • Clinical and histological features are often indistinct, leading to misdiagnosis.

Purpose of the Study:

  • To characterize the clinical presentation, histology, immunophenotype, and behavior of desmoplastic melanoma.
  • To differentiate DM from similar-appearing lesions.
  • To understand DM's distinct clinical course.

Main Methods:

  • Review of clinical and histopathological features of DM cases.
  • Immunohistochemical analysis for melanocytic markers (e.g., S-100, melanocyte differentiation antigens).
  • Comparison of DM with conventional melanoma regarding recurrence and metastasis rates.

Main Results:

  • DM presents with abundant fibrous stroma, often mimicking other lesions.
  • Immunophenotypically, DM is typically S-100 positive but may show weak or absent melanocytic antigen expression.
  • DM exhibits a higher rate of local recurrence but a lower rate of regional lymph node metastasis.

Conclusions:

  • Desmoplastic melanoma requires careful clinical and histological evaluation due to its potential for misdiagnosis.
  • Its unique immunophenotype and clinical behavior distinguish it from conventional melanoma.
  • Understanding these differences is crucial for appropriate patient management and prognosis.