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Related Experiment Video

Updated: Mar 26, 2026

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

Published on: May 10, 2021

Melanoma Margin Assessment.

Martin J Trotter¹

¹Department of Pathology and Laboratory Medicine, University of Calgary, Calgary Laboratory Services, 9-3535 Research Road NW, Calgary, Alberta, Canada T2L 2K8.

Surgical Pathology Clinics

|February 4, 2016

Summary

This summary is machine-generated.

Accurate surgical margin assessment is vital for primary cutaneous melanoma treatment. En face sectioning and immunohistochemistry improve melanoma detection, especially on sun-damaged skin.

Keywords:

Frozen sections Immunohistochemistry Margin assessment Melanoma in situ Zentigo maligna

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Last Updated: Mar 26, 2026

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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

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Published on: December 2, 2022

Area of Science:

Dermatopathology
Surgical Pathology

Background:

Primary cutaneous melanoma requires precise surgical excision and margin assessment.
Histologic evaluation of surgical margins is critical for accurate pathology reporting.
Conventional transverse sectioning inadequately samples melanoma margins.

Purpose of the Study:

To evaluate advanced techniques for surgical margin assessment in primary cutaneous melanoma.
To address challenges in margin assessment for melanoma on chronically sun-damaged skin.
To highlight the utility of en face sectioning and immunohistochemistry.

Main Methods:

Comparison of transverse versus en face sectioning techniques for margin assessment.
Discussion of diagnostic pitfalls in melanoma on sun-damaged skin.
Exploration of frozen sections and immunohistochemistry as ancillary methods.

Main Results:

En face techniques offer near-complete margin assessment compared to transverse methods.
Melanoma in situ diagnosis on sun-damaged skin presents specific challenges.
Immunohistochemistry aids in identifying in situ melanoma within surgical margins.

Conclusions:

En face sectioning is a superior method for assessing melanoma surgical margins.
Careful histologic assessment, including advanced techniques, is essential for optimal melanoma treatment.
Immunohistochemistry is a valuable tool for improving diagnostic accuracy in challenging cases.