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Updated: Mar 26, 2026
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Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
Published on: June 6, 2016
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Placental Mesenchymal Dysplasia
Ona Marie Faye-Petersen1, Raj P Kapur2
1Pathology, The University of Alabama at Birmingham, 619 19th Street South, NP 3547, Birmingham, AL 35249-7331, USA; Obstetrics and Gynecology, The University of Alabama at Birmingham, 619 19th Street South, NP 3547, Birmingham, AL 35249-7331, USA.
Surgical Pathology Clinics
|February 4, 2016
Summary
Placental mesenchymal dysplasia is a rare placental condition causing enlarged placentas with abnormal vessels. Diagnosis involves pathology, immunohistochemistry, and genetics, crucial for understanding pregnancy outcomes.
Area of Science:
- Reproductive biology
- Developmental biology
- Pathology
Background:
- Placental mesenchymal dysplasia (PMD) is a rare placental stromal lesion.
- Characterized by placentomegaly and abnormal chorionic plate and stem villous vessels.
- Prenatal features can mimic partial mole, but fetus is typically normal with diploid chromosomes.
Purpose of the Study:
- To discuss the pathologic features of PMD.
- To review current understanding of its etiopathogenesis.
- To highlight diagnostic methods and implications for pregnancy.
Main Methods:
- Pathologic examination of placental tissue.
- Immunohistochemical studies for diagnostic support.
- Molecular genetic studies for confirmation.
Main Results:
- PMD presents with specific placental abnormalities.
- Distinguished from partial mole by normal fetal and placental chromosomal complements.
- Diagnostic tools aid in accurate identification.
Conclusions:
- Understanding PMD's pathology and pathogenesis is crucial.
- Immunohistochemistry and molecular genetics are vital for diagnosis.
- Implications for pregnancy and infant outcomes require careful consideration.
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