Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.7K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.7K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.9K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.9K
Long-term Potentiation01:35

Long-term Potentiation

59.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.4K
Long-term Potentiation01:25

Long-term Potentiation

3.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.8K
Neuroplasticity01:01

Neuroplasticity

2.4K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.4K
Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early operative management in trauma: A nationwide comparison of time to surgery and survival at trauma centers and non-trauma centers.

Injury·2026
Same author

In response to the commentary by Cirelli et al. to our recent meta-analysis on spine changes following sleep deprivation.

Sleep·2025
Same author

Analyses of Nogo-Family Genes in Mouse and Human Microglia Omics Datasets Identify <i>LINGO1</i> as a Candidate Drug Target in Alzheimer's Disease.

Current neuropharmacology·2025
Same author

Sleep deprivation and dendritic architecture: a systematic review and meta-analysis.

Sleep·2025
Same author

Toxicological findings in Swedish cases of suspected drug-facilitated sexual assault (DFSA).

Scandinavian journal of clinical and laboratory investigation·2025
Same author

Optimizing Flow-Controlled Ventilation: Impact of I:E Ratios and Oxygen Concentration in a Porcine Model of Total Airway Obstruction.

Anesthesia and analgesia·2025

Related Experiment Video

Updated: Mar 26, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.9K

NgR1: A Tunable Sensor Regulating Memory Formation, Synaptic, and Dendritic Plasticity.

Tobias E Karlsson1, Gabriella Smedfors1, Alvin T S Brodin1

  • 1Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Cerebral Cortex (New York, N.Y. : 1991)
|February 4, 2016
PubMed
Summary

Nogo receptor 1 (NgR1) regulates memory and behavior. Impaired NgR1 function affects learning and synaptic plasticity, impacting brain development and responses to drugs like cocaine.

Keywords:
NgR1cocaine sensitizationdendritic structurespatial memoryspine plasticity

More Related Videos

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

7.0K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

853

Related Experiment Videos

Last Updated: Mar 26, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

14.9K
Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

7.0K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

853

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Molecular Biology

Background:

  • Nogo receptor 1 (NgR1) is crucial for nerve growth inhibition and is expressed in forebrain neurons.
  • Neuronal activity regulates NgR1 levels; impaired downregulation of NgR1 is linked to memory deficits.

Purpose of the Study:

  • To investigate the role of Nogo receptor 1 (NgR1) in behavioral paradigms and synaptic plasticity.
  • To examine the impact of NgR1 overexpression and deficiency on memory, locomotor behavior, and drug sensitization.

Main Methods:

  • Behavioral analysis in mice with altered NgR1 expression (overexpressing or lacking NgR1).
  • Assessment of locomotor behavior, recognition memory, and sequential spatial learning.
  • Investigation of cocaine-induced sensitization and effects on synaptic structures using ex vivo MRI and DTI.

Main Results:

  • Mice lacking NgR1 showed impaired locomotor behavior and recognition memory.
  • NgR1 overexpressing mice exhibited deficits in sequential spatial learning and altered responses to cocaine.
  • NgR1 overexpression reduced mature spine density and dendritic complexity, affecting cocaine-induced spine plasticity.

Conclusions:

  • Nogo receptor 1 (NgR1) acts as a negative regulator of structural synaptic plasticity and dendritic complexity in a region-specific manner.
  • The anterior cingulate cortex is identified as a key brain region for NgR1-mediated memory plasticity.
  • NgR1 plays a significant role in regulating behavioral responses and synaptic adaptations.