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Updated: Mar 26, 2026

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
Cellular Fibromatous Neoplasms of the Ovary
1Department of Pathology, University of British Columbia, Canada; Department of Laboratory Medicine, Pathology, and Medical Genetics, Royal Jubilee Hospital, 1952 Bay Street, Victoria, BC, Canada V8R 1J8.
Abstract:
Many ovarian tumors composed primarily of fibroblastic cells are fibromas of usual type, and generally do not pose diagnostic difficulty. These tumors can be diagnosed accurately in most instances based on morphology without needing immunohistochemistry. Approximately 10% of fibromatous neoplasms, however, exhibit increased cellularity and mitotic activity, and, in the presence of the former or both features, are classified as cellular fibroma or mitotically active cellular fibroma. Distinguishing these entities from fibrosarcoma, an exceptionally uncommon ovarian malignancy, is important. This article reviews fibromatous ovarian tumors, emphasizing cellular fibromas and their differential diagnosis.
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