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Characterization and application of roxithromycin loaded cyclodextrin based nanoparticles for treatment of multidrug

Farha Masood1, Tariq Yasin2, Habib Bukhari1

  • 1Department of Biosciences, COMSATS Institute of Information Technology (CIIT), Islamabad, Pakistan.

Materials Science & Engineering. C, Materials for Biological Applications
|February 4, 2016
PubMed

Insights

This study developed novel nanoparticles for roxithromycin (ROX) to combat multidrug-resistant (MDR) bacteria. The hydroxypropyl-β-cyclodextrin (HPβCD)-ROX/PLGA nanoparticles demonstrated significant antibacterial activity against MDR strains.

Area of Science:

  • Pharmaceutical Nanotechnology
  • Drug Delivery Systems
  • Antimicrobial Resistance

Background:

  • Multidrug-resistant (MDR) bacterial infections pose a significant global health threat.
  • Roxithromycin (ROX), a class IV antibiotic, suffers from poor solubility, limiting its therapeutic efficacy.
  • Effective drug delivery systems are crucial for overcoming challenges associated with MDR infections.

Purpose of the Study:

  • To develop and characterize novel nanoparticle formulations for enhanced delivery of roxithromycin (ROX).
  • To improve the solubility and therapeutic potential of ROX against multidrug-resistant (MDR) bacteria.
  • To evaluate the antibacterial activity of ROX-loaded nanoparticles against selected MDR bacterial strains.

Main Methods:

  • Encapsulation of roxithromycin (ROX) within β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD).
  • Loading of ROX-cyclodextrin inclusion complexes into poly-(lactic-co-glycolic acid) (PLGA) to form nanoparticles (NPs).
  • Preparation of blank and ROX-loaded PLGA nanoparticles for comparison.

Main Results:

  • Hydroxypropyl-β-cyclodextrin-ROX/PLGA (HPβCD-ROX/PLGA) nanoparticles exhibited higher ROX loading efficiency compared to other formulations.
  • All synthesized nanoparticle formulations demonstrated significant (P<0.0001) antibacterial activity against MDR bacterial strains.
  • The developed nanoparticle systems showed promising results in enhancing ROX delivery.

Conclusions:

  • HPβCD-ROX/PLGA nanoparticles represent a promising strategy for improving roxithromycin solubility and delivery.
  • These novel delivery systems hold significant therapeutic potential for combating infections caused by multidrug-resistant bacteria.
  • Further research into these nanocarriers could lead to advanced treatments for antimicrobial resistance.
Keywords:
Antimicrobial activityCyclodextrinInclusion complexNanoparticlesPoly-(lactic-co-glycolic acid)Roxithromycin

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