Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

1.8K
1.8K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.4K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
6.5K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Autocrine Signaling01:01

Autocrine Signaling

52.9K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
52.9K
Autocrine Signaling01:01

Autocrine Signaling

4.2K
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of GLUT1 Ameliorates Thickening of the Glomerular Basement Membrane via the Rheb/mTORC1 Pathway in Diabetic Nephropathy.

Diabetes·2026
Same author

Warm-core eddy intensifies surface mixotrophic bacterivory and fuels mesopelagic heterotrophic grazing.

Communications biology·2026
Same author

Hedgehog-driven adaxial cell constriction patterns slow muscle fate and somite boundary remodeling in the presomitic mesoderm.

Cell reports·2026
Same author

Hedgehog pathway activity downstream of Smoothened is regulated specifically by basal ciliary PKA.

Cellular & molecular biology letters·2026
Same author

Temperature-dependent effects of lanthanum-modified bentonite on sediment nitrogen removal processes and the underlying microbial mechanisms.

Water research·2026
Same author

Research on evaluation indicator and method of stand quality.

Scientific reports·2025

Related Experiment Video

Updated: Mar 26, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

1.2K

Hedgehog signalling.

Raymond Teck Ho Lee1, Zhonghua Zhao2, Philip W Ingham3

  • 1Developmental and Biomedical Genetics Laboratory, Institute of Molecular and Cell Biology, Agency of Science, Technology and Research (A* STAR), Singapore, 138673 Singapore.

Development (Cambridge, England)
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

The Hedgehog (Hh) signalling pathway regulates development and morphogen activity. Understanding Hh mechanisms is crucial for developmental biology, disease research, and potential therapies.

Keywords:
DrosophilaHedgehog signallingVertebrate

More Related Videos

Efficient and Cost Effective Electroporation Method to Study Primary Cilium-Dependent Signaling Pathways in the Granule Cell Precursor
04:06

Efficient and Cost Effective Electroporation Method to Study Primary Cilium-Dependent Signaling Pathways in the Granule Cell Precursor

Published on: November 30, 2021

2.8K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K

Related Experiment Videos

Last Updated: Mar 26, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

1.2K
Efficient and Cost Effective Electroporation Method to Study Primary Cilium-Dependent Signaling Pathways in the Granule Cell Precursor
04:06

Efficient and Cost Effective Electroporation Method to Study Primary Cilium-Dependent Signaling Pathways in the Granule Cell Precursor

Published on: November 30, 2021

2.8K
Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

11.9K

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Signalling

Background:

  • The Hedgehog (Hh) signalling pathway is a critical regulator of embryonic development in metazoans.
  • Hh proteins function as classical morphogens, influencing cell fate and tissue patterning.
  • Aberrations in Hh signalling are linked to developmental disorders and diseases, highlighting its therapeutic relevance.

Purpose of the Study:

  • To outline the current understanding of Hedgehog signalling mechanisms.
  • To highlight conserved and divergent aspects of Hh signalling across different species.
  • To provide a resource for researchers in developmental biology, evo-devo, cancer, and regenerative medicine.

Main Methods:

  • Review and synthesis of existing literature on Hh signalling.
  • Comparative analysis of Hh pathway components and functions across species.
  • Integration of data from various research fields including developmental biology and cancer research.

Main Results:

  • Detailed overview of the Hh signalling cascade, including ligand production, reception, and downstream effects.
  • Identification of key similarities and differences in Hh pathway operation across diverse organisms.
  • Emphasis on the role of Hh signalling in both normal development and disease states.

Conclusions:

  • The Hedgehog signalling pathway is a fundamental biological process with broad implications.
  • Understanding species-specific variations in Hh signalling is essential for targeted research and therapeutic development.
  • This work serves as a foundational summary of Hh signalling mechanisms and their significance.