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Cancer Therapy-Related Cardiac Dysfunction and Heart Failure: Part 2: Prevention, Treatment, Guidelines, and Future
Carine E Hamo1, Michelle W Bloom1, Daniela Cardinale1
1From the Cardiology Division (C.E.H., M.W.B, H.S., J.B.) and Oncology Division, Stony Brook University, NY (L.B.); Oncology Division, European Institute of Oncology, Milan, Italy (D.C.); Cardiology Division, University of Pennsylvania, Philadelphia (B.K.); Cardiology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.N.); Cardiology Division, Vanderbilt University, Nashville, TN (D.J.L.); Cardiology Division, Center for Cardiovascular Innovation, Northwestern Feinberg School of Medicine, Chicago, IL (M.G.); and Cardiovascular Division, NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital and Imperial College London, London, United Kingdom (A.R.L.).
Cancer therapies can cause heart problems like left ventricular dysfunction. This review covers prevention and treatment strategies for cancer therapy-related cardiac dysfunction, highlighting research gaps.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Cancer treatments improve survival but can lead to cardiac complications.
- Cancer therapy-related cardiac dysfunction (CTRCD) is a growing concern, impacting patient outcomes.
- Existing knowledge on CTRCD mechanisms lacks evidence-based monitoring and management guidelines.
Purpose of the Study:
- To review the prevention and treatment strategies for cancer therapy-related cardiac dysfunction.
- To identify evidence gaps and future research directions in managing CTRCD.
Main Methods:
- Literature review focusing on prevention and treatment of CTRCD.
- Analysis of current evidence on managing cardiac toxicity in cancer patients.
Main Results:
- Discusses various prevention and treatment modalities for CTRCD.
- Highlights the need for standardized approaches in managing cardiac complications.
- Identifies areas requiring further research to improve patient care.
Conclusions:
- Effective prevention and treatment strategies are crucial for managing CTRCD.
- Further research is needed to establish evidence-based guidelines for monitoring and management.
- Addressing these gaps will improve long-term outcomes for cancer survivors.
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