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Updated: Mar 26, 2026

Isolating Mesangiogenic Progenitor Cells MPCs from Human Bone Marrow
Published on: July 15, 2016
Multiple Functions of MSCA-1/TNAP in Adult Mesenchymal Progenitor/Stromal Cells
David Estève1, Jean Galitzky1, Anne Bouloumié1
1Inserm UMR 1048, Team 1, Institute of Metabolic and Cardiovascular Diseases, Paul Sabatier University, 1 avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
Abstract:
Our knowledge about mesenchymal stem cells has considerably grown in the last years. Since the proof of concept of the existence of such cells in the 70s by Friedenstein et al., a growing mass of reports were conducted for a better definition of these cells and for the reevaluation from the term "mesenchymal stem cells" to the term "mesenchymal stromal cells (MSCs)." Being more than a semantic shift, concepts behind this new terminology reveal the complexity and the heterogeneity of the cells grouped in MSC family especially as these cells are present in nearly all adult tissues. Recently, mesenchymal stromal cell antigen-1 (MSCA-1)/tissue nonspecific alkaline phosphatase (TNAP) was described as a new cell surface marker of MSCs from different tissues. The alkaline phosphatase activity of this protein could be involved in wide range of MSC features described below from cell differentiation to immunomodulatory properties, as well as occurrence of pathologies. The present review aims to decipher and summarize the role of TNAP in progenitor cells from different tissues focusing preferentially on brain, bone marrow, and adipose tissue.
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