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Stable isotopes as tracers in clinical research
P J Pacy1, K N Cheng, G N Thompson
1Nutrition Research Group, Clinical Research Centre, Harrow, UK.
Annals of Nutrition & Metabolism
|January 1, 1989
Summary
Stable isotopes are becoming more accessible and affordable for medical research. They are poised to replace radioactive isotopes in human metabolic studies soon.
Area of Science:
- Medical research
- Biochemistry
- Analytical chemistry
Background:
- Stable isotopes offer a safer alternative to radioactive isotopes.
- Advancements in analytical instrumentation enhance detection capabilities.
Purpose of the Study:
- To highlight the growing importance of stable isotopes in medical research.
- To predict the future role of stable isotopes in quantitative metabolic studies.
Main Methods:
- Review of current trends in stable isotope availability and cost.
- Analysis of the capabilities of modern analytical instruments.
Main Results:
- Stable isotope-labeled substrates are increasingly available and cost-effective.
- Sensitive analytical instruments are readily accessible for research.
Conclusions:
- Stable isotopes are expected to become standard in all medical research fields.
- Radioactive isotopes will likely be superseded by stable isotopes in human metabolic studies.