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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

649
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
649

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Related Experiment Video

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Quantifying disease progression in amyotrophic lateral sclerosis using peripheral nerve sonography.

Stefanie Schreiber1,2, Verena Dannhardt-Stieger1,2, Dorothea Henkel1

  • 1Department of Neurology, Otto-von-Guericke University, Leipziger Strasse 44, 39120, Magdeburg, Germany.

Muscle & Nerve
|February 4, 2016
PubMed
Summary

Peripheral nerve ultrasound shows promise for monitoring amyotrophic lateral sclerosis (ALS) progression. Ulnar nerve cross-sectional area (CSA) decline may serve as a biomarker, potentially detectable in clinical trials.

Keywords:
amyotrophic lateral sclerosisbiomarkercross-sectional areamedian nerveulnar nerveultrasound

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Area of Science:

  • Neurology
  • Medical Imaging
  • Biomarkers

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Monitoring disease progression is crucial for clinical trials and patient management.
  • Non-invasive biomarkers are needed to track ALS progression.

Purpose of the Study:

  • To investigate peripheral nerve sonography as a biomarker for ALS progression.
  • To assess the utility of nerve cross-sectional area (CSA) changes over time in ALS patients.

Main Methods:

  • 37 ALS patients underwent serial ultrasound assessments of ulnar and median nerve CSA.
  • Mean follow-up duration was 14.5 months.
  • Linear mixed-effects models analyzed time-dependent changes in CSA.

Main Results:

  • Significant monthly decline in ulnar nerve CSA observed (-0.04 mm² forearm, -0.05 mm² wrist).
  • Ulnar nerve CSA decrease was more pronounced with larger baseline measurements.
  • Median nerve CSA showed no significant changes over time.
  • A hypothetical clinical trial would require 332 patients to detect a 50% treatment effect on ulnar nerve CSA.

Conclusions:

  • Distal ulnar nerve ultrasound is a potential biomarker for monitoring ALS progression.
  • This method may be suitable for detecting treatment effects in manageable clinical trial cohort sizes.