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Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study

Richard L Amdur1,2, Monica Mukherjee3, Alan Go4

  • 1Biostatistics core, George Washington University Medical Faculty Associates, Washington, DC, United States of America.

Plos One
|February 4, 2016
PubMed

Insights

Interleukin-6 (IL-6) inflammation is linked to atrial fibrillation (AF) in chronic kidney disease (CKD) patients. This study found elevated IL-6 levels independently predict AF presence and new onset in CKD individuals.

Area of Science:

  • Nephrology
  • Cardiology
  • Immunology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia in chronic kidney disease (CKD) patients.
  • Inflammation is increasingly recognized as a contributing factor in cardiovascular diseases, including AF.

Purpose of the Study:

  • To investigate the association between inflammatory biomarkers and AF in a large cohort of CKD patients.
  • To determine if specific inflammatory markers predict the presence or new onset of AF.

Main Methods:

  • Analysis of 3,762 adult CKD patients from the Chronic Renal Insufficiency Cohort (CRIC) study.
  • Measurement of plasma inflammatory markers (IL-1, IL-1RA, IL-6, TNF-α, TGF-β, hs-CRP, fibrinogen) at baseline.
  • AF assessed by self-report and ECG at baseline, with new-onset AF tracked over a mean 3.7-year follow-up.

Main Results:

  • No significant association between inflammatory biomarkers and past history of AF.
  • Plasma IL-6 levels were significantly associated with the presence of AF at baseline (OR, 1.61; P = 0.001).
  • Elevated IL-6 independently predicted new-onset AF during follow-up (OR, 1.25; P = 0.03).

Conclusions:

  • Plasma IL-6 is an independent and consistent predictor of AF in patients with CKD.
  • Inflammation, specifically IL-6, plays a significant role in the pathophysiology of AF in the CKD population.

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