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Association Between Metabolic Control and Lipid Parameters in Indian Children with Type 1 Diabetes

Lavanya Parthasarathy1, Shashi Chiplonkar, Vaman Khadilkar

  • 1Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. Correspondence to: Dr Anuradha Khadilkar, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32 Sassoon Road, Pune.411 001, India. anuradhavkhadilkar@gmail.com.

Indian Pediatrics
|February 4, 2016
PubMed

Insights

Diabetic children exhibit poorer lipid profiles, with higher LDL-C and lower HDL-C. Improving glycemic control (HbA1c) and physical activity are key to reducing cardiometabolic risk in pediatric diabetes.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Risk Management
  • Metabolic Disorders

Background:

  • Children with diabetes often experience dyslipidemia, a significant risk factor for cardiovascular disease.
  • Understanding the relationship between metabolic control and lipid profiles is crucial for early intervention.

Purpose of the Study:

  • To compare lipid parameters between diabetic children and healthy controls.
  • To investigate the association between glycemic control (HbA1c) and lipid profiles in pediatric diabetes.
  • To assess the impact of physical activity on lipid levels.

Main Methods:

  • Lipid profiles and HbA1c levels were measured in 80 diabetic children and 54 controls.
  • Measurements were repeated after one year in 45 diabetic participants.
  • Statistical analyses were performed to determine associations and differences.

Main Results:

  • Diabetic children had significantly higher LDL-C and lower HDL-C compared to controls.
  • Glycemic control (HbA1c) was a strong predictor of total and LDL-C levels.
  • Improved HbA1c correlated with reduced LDL-C, while deteriorated HbA1c was linked to increased LDL-C.
  • Moderate physical activity was associated with protection against high LDL-C levels.

Conclusions:

  • Improving metabolic control is essential for reducing cardiometabolic risk in diabetic children.
  • Physical activity plays a beneficial role in managing lipid profiles and mitigating cardiovascular risk.
Abstract

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