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Updated: Mar 26, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
[Methotrexate - anchor drug in the treament of rheumatoid arthritis]
Abstract:
Methotrexate is in the centre of the treatment of rheumatoid arthritis. There are new insights in the understanding of its mechanism: intracellular polyglutamation activates the methotrexate molecule. The magnitude of this step is associated with response to the treatment. Further on, it was found that even low doses of methotrexate are sufficient to guarantee its effect as comedication of TNF-inhibitors. Finally, from the follow-up of long term cohorts it seems that methotrexate reduces mortality in rheumatoid arthritis independently from its effect on disease activity.
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