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Updated: Mar 26, 2026
11:56
Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
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Oritavancin: A Novel Lipoglycopeptide.
Jacob Mattox1, Paul Belliveau, Cheryl Durand
1MCPHS University/Pfizer Biopharmaceutical Industry Fellowship, Pfizer Inc, Groton, Connecticut, USA.
Summary
Oritavancin is a new lipoglycopeptide antibiotic effective against gram-positive bacteria, including resistant strains. Its favorable pharmacokinetics allow for single-dose administration in acute bacterial skin infections.
Area of Science:
- Pharmacology and Microbiology
- Infectious Diseases
Background:
- Oritavancin is a novel lipoglycopeptide antibiotic.
- It exhibits broad-spectrum activity against Gram-positive pathogens.
Purpose of the Study:
- To review the pharmacology, pharmacokinetics, safety, and efficacy of oritavancin.
- To evaluate its potential role in treating acute bacterial skin and skin structure infections (ABSSSI).
Main Methods:
- Literature search of MEDLINE and PubMed for oritavancin.
- Inclusion of FDA package insert and EMA guidances for ABSSSI.
- Evaluation of data from all clinical development stages.
Main Results:
- Oritavancin demonstrates potent activity against Gram-positive organisms, including resistant strains.
- It has a prolonged half-life (245 hours) allowing for single-dose administration.
- Clinical trials show oritavancin is well-tolerated and non-inferior to vancomycin for ABSSSI.
Conclusions:
- Oritavancin (Orbactiv) is FDA-approved for ABSSSI treatment.
- Its unique profile includes reduced dosing and efficacy against resistant pathogens.
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