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Updated: Mar 26, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
The rise, fall, and possible resurrection of renal denervation
Rajiv Gulati1, Claire E Raphael2, Manuela Negoita3
1Division of Cardiovascular Diseases and Department of Internal Medicine, Mayo Clinic, 200 First Street, Rochester, Minnesota 55905, USA.
Abstract:
Renal denervation has a chequered history. Dramatic reductions in blood pressure after denervation of the renal arteries were observed in early trials, but later trials in which denervation was tested against a sham procedure produced neutral results. Although a sound pathophysiological basis exists for interruption of the renal sympathetic nervous system as a treatment for hypertension, trial data to date are insufficient to support renal denervation as an established clinical therapy. In this Perspectives article, we summarize the currently available trial data, device development, and trials in progress, and provide recommendations for future trial design.
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