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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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Depression: Overview01:18

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Long-term Depression01:03

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
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Long-term Depression01:05

Long-term Depression

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Mental health service delivery to older people in New South Wales: perceptions of aged care, adult mental health and mental health services for older people.

The Australian and New Zealand journal of psychiatry·2003
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Updated: Mar 26, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
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Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

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Depression in dementia.

David Kitching1

  • 1Senior psychiatry specialist, Concord Hospital, Sydney.

Australian Prescriber
|February 5, 2016
PubMed
Summary

Major depression is common in dementia patients and can be a risk factor for developing dementia. Effective management involves both non-drug and drug therapies, aiming to improve quality of life.

Area of Science:

  • Geriatric Medicine
  • Neurology
  • Psychiatry

Background:

  • Major depression frequently co-occurs with dementia, impacting patient well-being.
  • A first major depressive episode in older adults is a recognized risk factor for dementia development.

Purpose of the Study:

  • To outline key considerations for managing depression in individuals with dementia.
  • To emphasize the importance of a multidisciplinary approach and optimized quality of life.

Main Methods:

  • Review of current literature on depression management in dementia.
  • Discussion of non-pharmacological and pharmacological treatment strategies.
  • Highlighting the role of selective serotonin reuptake inhibitors (SSRIs).

Main Results:

Keywords:
Alzheimer’s diseaseantidepressantsdementiadepression

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  • Depression management in dementia requires an enthusiastic approach focused on quality of life.
  • Both non-pharmacological and pharmacological interventions are crucial.
  • SSRIs are first-line pharmacotherapy but may have reduced efficacy in older adults.

Conclusions:

  • Collaborative management is essential for patients with dementia and depression.
  • Optimizing quality of life should be the primary goal of treatment.
  • Careful consideration of pharmacotherapy, including SSRIs, is necessary, acknowledging potential limitations in the elderly population.