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Stride-Time Variability and Fall Risk in Persons with Multiple Sclerosis.

Yaejin Moon1, Douglas A Wajda1, Robert W Motl1

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 906 S. Goodwin Avenue, Urbana, IL 61801, USA.

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Summary
This summary is machine-generated.

Gait variability, measured by stride-time CV, is strongly linked to fall risk in people with Multiple Sclerosis (PwMS). Postural sway may be a key factor to target for improving gait in PwMS.

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Area of Science:

  • Neurology
  • Biomechanics
  • Gerontology

Background:

  • Gait variability is a known fall predictor in various clinical groups.
  • The relationship between gait variability and falls in persons with Multiple Sclerosis (PwMS) requires further investigation.

Purpose of the Study:

  • To examine the association between stride-time variability, fall risk, and physiological fall risk factors in PwMS.
  • To compare these associations in PwMS and age-matched controls.

Main Methods:

  • 17 PwMS and 17 controls underwent a 6-minute walk test with shank-mounted accelerometers to measure stride-time variability (interstride CV).
  • Fall risk was assessed using the short form Physiological Profile Assessment (PPA).
  • Spearman correlation analysis was employed to determine relationships between variables.

Main Results:

  • Increased fall risk strongly correlated with increased stride-time CV in both PwMS (ρ = 0.71) and controls (ρ = 0.67).
  • Average stride-time did not correlate with fall risk in either group.
  • In PwMS, stride-time CV was linked to postural sway (ρ = 0.74); in controls, it related to proprioception (ρ = 0.61) and postural sway (ρ = 0.78).

Conclusions:

  • Gait variability (stride-time CV) appears to be a more sensitive marker of fall risk than average gait parameters in PwMS.
  • Postural sway may be a potential therapeutic target for modifying gait variability and reducing fall risk in PwMS.