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Related Experiment Videos

Polyhydroxybutyrate as a drug carrier.

F Koosha1, R H Muller, S S Davis

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Nottingham, United Kingdom.

Critical Reviews in Therapeutic Drug Carrier Systems
|January 1, 1989
PubMed
Summary

Polyhydroxybutyrate (PHB) shows promise as a biocompatible and non-toxic alternative for drug delivery systems. Further research is needed to clarify its biodegradation in humans for effective drug carrier applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Polyhydroxybutyrate (PHB) is a biodegradable polymer produced by bacteria, serving as an energy and carbon source.
  • PHB is being explored as a potential substitute for polylactide-glycolides in pharmaceutical applications.
  • Key properties for drug carriers include biocompatibility, biodegradability, and non-toxicity.

Purpose of the Study:

  • To evaluate Polyhydroxybutyrate (PHB) as a viable alternative polymer for the development of drug carriers.
  • To assess the biocompatibility, biodegradability, and toxicity profile of PHB for pharmaceutical use.

Main Methods:

  • Review of existing literature on Polyhydroxybutyrate (PHB) properties and applications.
  • Analysis of PHB's chemical synthesis and extraction methods.

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  • Evaluation of PHB's suitability based on established criteria for drug delivery materials.

    • Main Results:

    • PHB is a linear homopolymer synthesized from D(-)-β-hydroxybutyric acid.
    • The polymer demonstrates biocompatibility and is non-toxic, with its monomer well-tolerated.
    • PHB biodegrades into carbon dioxide in bacteria, but human biodegradation data is limited and conflicting.

    Conclusions:

    • Polyhydroxybutyrate (PHB) presents a promising, non-toxic biomaterial for drug carrier applications.
    • Its biocompatibility is established, but human biodegradation requires further investigation.
    • Potential applications include controlled-release implants, particulates, and targeted intravenous colloidal carriers.