Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ex vivo expansion of hematopoietic stem and progenitor cells from human mobilized peripheral blood for gene therapy applications.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.

bioRxiv : the preprint server for biology·2026

Same author

Simultaneous orthogonal cell engineering by a single CRISPR-Cas9 polyfunctional editor.

Nature communications·2026

Same author

Genome-wide association study of copy number variations in Parkinson's disease.

NPJ Parkinson's disease·2026

Same author

T cells dressed up with a dual HLA-restricted TCR targeting cathepsin G drive effective AML eradication.

Blood·2026

Same author

Iron overload damages mitochondria and induces metabolic rewiring of hematopoietic stem cells toward glycolysis.

Blood·2026

Same journal

Extracellular Vesicles from Mesenchymal Stem Cells Alleviate Spinal Cord Injury via the miR-486-5p/PTEN/PI3K/AKT Pathway.

Current drug targets·2026

Same journal

Improving B-cell Linear Epitope Prediction <i>via</i> Multiple Feature Fusion and an Integrated Machine Learning Algorithm.

Current drug targets·2026

Same journal

Mechanistic Insights into the Inhibition of Plasmodium falciparum DNA Gyrase A by Withanolide Derivatives through Integrated Computational Analysis.

Current drug targets·2026

Same journal

Epitranscriptomics in Breast Cancer: The Unveiled Role of RNA Modifications.

Current drug targets·2026

Same journal

Neuroinflammation in Alzheimer's Disease: New Approaches.

Current drug targets·2026

Same journal

FXYD3: A Key Regulator of Ion Homeostasis and Redox Balance in Cancer Biology.

Current drug targets·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

High Content Screening in Neurodegenerative Diseases

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

Portals and Web-Based Resources for Virtual Screening.

Jens Krüger¹, Philipp Thiel, Ivan Merelli

¹Applied Bioinformatics Group, Department of Computer Science, Eberhard Karls Universität Tübingen, Sand 14, 72076 Tübingen, Germany.

Current Drug Targets

|February 5, 2016

Summary

This summary is machine-generated.

Virtual screening accelerates drug discovery by predicting compound binding modes. This review guides researchers through available online tools for compound databases and docking applications, ensuring scientifically reliable results.

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Published on: September 28, 2022

Related Experiment Videos

Last Updated: Mar 26, 2026

High Content Screening in Neurodegenerative Diseases

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Bridging the Technology Divide in the COVID-19 Era: Using Virtual Outreach to Expose Middle and High School Students to Imaging Technology

Published on: September 28, 2022

Area of Science:

Computational chemistry
Drug discovery
Structural biology

Background:

Virtual screening is crucial for efficient drug development.
Computer-based prediction of compound binding modes saves time and cost.
Selecting appropriate computational tools is vital for researchers.

Purpose of the Study:

To provide an overview of online resources for drug discovery and virtual screening.
To assist structural biologists in choosing optimal analysis tools.
To discuss key aspects of user interface, security, data management, and performance.

Main Methods:

Literature review of online resources.
Analysis of compound databases and docking applications.
Evaluation of science gateways for drug discovery.

Main Results:

Identification of key online resources for virtual screening.
Discussion of user interface, security, data management, and computational performance factors.
Categorization of tools to aid researchers in selection.

Conclusions:

A comprehensive overview of virtual screening resources is presented.
Guidance is provided for selecting appropriate computational tools.
The review aims to enhance the reliability of drug discovery results.