Self-Healing Spongy Coating for Drug "Cocktail" Delivery

Xia-chao Chen¹, Ke-feng Ren¹, Wen-xi Lei¹

¹MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, China.

|February 5, 2016

Abstract:

Optimized ratio in the codelivery of therapeutics is of crucial importance to promote the synergism rather than the antagonistic effects. In this study, a self-healing spongy coating was described to facilitate the surface-mediated delivery of drug "cocktails" proportionally. The formation of spongy structures within the coating was achieved by acidic treatment and freeze-drying. Various drug combinations can be readily integrated through wicking method and subsequent micropore self-healing. The ratio of drug loading can be precisely regulated by the composition of loading solution and the embedded drugs were released in proportion according to the initial ratio of drug combination.

Keywords:

drug combination polyelectrolyte multilayers proportional codelivery self-healing spongy coating

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Abstract:

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