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Updated: Mar 26, 2026

Functional Assessment of Intestinal Tight Junction Barrier and Ion Permeability in Native Tissue by Ussing Chamber Technique
Published on: May 26, 2021
Importance of Tight Junctions in Relation to Skin Barrier Function
1Department of Dermatology and Venerology, Laboratory for Cell and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Abstract:
Tight junctions (TJs) are complex cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. Besides forming a barrier themselves, TJs influence other skin barriers, e.g. the stratum corneum barrier, and are influenced by other skin barriers, e.g. by the chemical, the microbiome, or the immunological barrier and likely by the basement membrane. This review summarizes the dynamic interaction of the TJ barrier with other barriers in the skin and the central role of TJs in skin barrier function.
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