Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

3.3K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.3K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

10.7K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
10.7K
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

16.1K
The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
16.1K
The Skin Microbiota01:27

The Skin Microbiota

20
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
20
Allergic Reactions02:06

Allergic Reactions

33.5K
Overview
33.5K
Sensory Functions of the Skin01:16

Sensory Functions of the Skin

9.3K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomic profiling of tear fluid in patients with atopic keratoconjunctivitis.

The ocular surface·2026
Same author

Crosslinked Fibrin Fragment (X-FIB) as a Biomarker for Endotype Differentiation and Response to Omalizumab Treatment in Chronic Spontaneous Urticaria.

Allergy·2025
Same author

The Prevalence and Severity of Hand Eczema Among Adults in Tasiilaq, East Greenland.

Contact dermatitis·2025
Same author

Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration.

Allergy·2024
Same author

Increased loss-of-function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta-analysis.

Experimental dermatology·2024
Same author

Parents of children with atopic diseases - experiences with care and the interaction with healthcare professionals over time.

Scandinavian journal of primary health care·2024

Related Experiment Video

Updated: Mar 26, 2026

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
09:09

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Published on: February 24, 2021

3.4K

Skin Barrier Function and Allergens.

Kristiane Aasen Engebretsen, Jacob Pontoppidan Thyssen

    Current Problems in Dermatology
    |February 5, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Skin barrier function impacts allergy development. While psoriasis and atopic dermatitis show complex relationships with contact allergy, irritant contact dermatitis significantly increases allergy risk due to compromised skin barrier and inflammation.

    More Related Videos

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
    08:02

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

    Published on: March 24, 2023

    5.2K
    Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
    05:58

    Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

    Published on: April 20, 2016

    19.8K

    Related Experiment Videos

    Last Updated: Mar 26, 2026

    Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
    09:09

    Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

    Published on: February 24, 2021

    3.4K
    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
    08:02

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

    Published on: March 24, 2023

    5.2K
    Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
    05:58

    Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

    Published on: April 20, 2016

    19.8K

    Area of Science:

    • Immunology
    • Dermatology
    • Allergy Research

    Background:

    • The skin barrier is crucial for protection against environmental factors and preventing water loss.
    • Compromised skin barrier function in dermatoses may increase susceptibility to contact sensitization (CS) and allergy.
    • The interplay between skin barrier status, immune responses, and the development of contact allergy (CA) is complex.

    Purpose of the Study:

    • To explore the intricate relationship between common dermatoses (psoriasis, atopic dermatitis, irritant contact dermatitis) and the risk of developing contact allergy.
    • To elucidate the immunological mechanisms, including T-helper cell responses and cytokine profiles, influencing these associations.
    • To understand how skin barrier integrity and inflammation mediate the risk of contact sensitization and subsequent allergy.

    Main Methods:

    • Review of existing research on psoriasis, atopic dermatitis (AD), and irritant contact dermatitis (ICD) in relation to contact allergy (CA) and contact sensitization (CS).
    • Analysis of immunological data, including T-helper 1 (Th1), T-helper 2 (Th2), and T-helper 17 (Th17) cell involvement and associated cytokines (e.g., IL-17, IL-1, TNF-α).
    • Examination of experimental and epidemiological evidence linking skin barrier disruption and inflammation to sensitization pathways.

    Main Results:

    • Psoriasis may have an inverse relationship with CA, potentially due to elevated Th17 cell activity.
    • Atopic dermatitis (AD) shows conflicting associations with CS; epidemiological studies suggest a positive link, while experimental data indicate an inverse relationship, possibly due to Th1/Th2 antagonism.
    • Irritant contact dermatitis (ICD) strongly correlates with an increased risk of CS and CA, driven by inflammatory mediators like IL-1 and TNF-α that enhance antigen presentation.

    Conclusions:

    • The development of contact allergy is significantly influenced by the type of dermatosis and its underlying immunological and barrier characteristics.
    • Skin barrier impairment and inflammation, particularly in irritant contact dermatitis, are key drivers for the development of contact sensitization and allergy.
    • Understanding these complex interactions is vital for predicting and potentially preventing allergic contact dermatitis in patients with various skin conditions.