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Penetration through the Skin Barrier.

Jesper Bo Nielsen, Eva Benfeldt, Rikke Holmgaard

    Current Problems in Dermatology
    |February 5, 2016
    PubMed
    Summary
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    This study explores percutaneous penetration, focusing on how skin characteristics and chemical properties influence drug delivery through the skin. It reviews various methods for measuring and predicting this penetration for improved treatment planning.

    Area of Science:

    • Dermatology
    • Pharmacokinetics
    • Biophysics

    Background:

    • The skin acts as a vital barrier, regulating homeostasis and selectively allowing chemical passage.
    • Percutaneous drug delivery is increasingly important, necessitating research into skin penetration.
    • Factors influencing skin barrier function have been previously discussed.

    Purpose of the Study:

    • To introduce the theory of barrier penetration, specifically Fick's law.
    • To describe and discuss methods for measuring the kinetics of percutaneous chemical penetration.
    • To analyze how skin and penetrant characteristics affect percutaneous penetration kinetics.

    Main Methods:

    • In vitro methods: static and flow-through diffusion cells.
    • In vivo methods: microdialysis and microperfusion.

    Related Experiment Videos

  • Theoretical framework: Fick's law of diffusion.

    • Main Results:

    • Skin characteristics (age, site, integrity) significantly impact penetration rates.
    • Chemical properties (size, solubility, ionization, logPow, vehicles) influence kinetics.
    • Various methods offer different advantages and challenges for evaluating percutaneous penetration.

    Conclusions:

    • Understanding percutaneous penetration kinetics is crucial for effective drug delivery.
    • Methodological choices impact the evaluation of skin penetration.
    • This knowledge aids in decision-making for treatment planning and experimental study evaluation.