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Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers
Jung Bok Lee1,2, Xintong Wang1, Shannon Faley2
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Advanced Healthcare Materials
|February 5, 2016
Abstract:
A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.
