Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

3.0K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
3.0K
Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

2.0K
Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
2.0K
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:22

Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

2.5K
Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
The direct-acting...
2.5K
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:29

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

1.1K
Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
1.1K
Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

4.1K
Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of...
4.1K
Direct-Acting Cholinergic Agonists: Pharmacological Actions00:59

Direct-Acting Cholinergic Agonists: Pharmacological Actions

2.5K
Direct-acting cholinergic agonists exert their pharmacological actions by mimicking the effects of acetylcholine on postsynaptic muscarinic receptors to generate parasympathetic responses. These agents elicit a range of physiological responses, including cardiovascular effects. For example, activation of muscarinic receptors induces bradycardia, decreased cardiac output, reduced peripheral resistance, and consequent hypotension. In the eye, stimulation of M3 receptors leads to smooth muscle...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Low-Fat Diet Combined with Different Exercise Interventions on Weight Loss Maintenance in Adults: A Network Meta-Analysis.

Endocrine·2026
Same author

Fluoro-Wacker <i>Gem</i>-Difluorination of Alkene via Fluoropalladation and Dyotropic Rearrangement.

Journal of the American Chemical Society·2026
Same author

TiCl<sub>3</sub>-Mediated Reductive Aminohydroxylation of Alkenes to (Benzo)Furo[3,2-<i>b</i>]Indolines.

Organic letters·2026
Same author

Ynimines as versatile precursors to 2-imido- and 2-amido-1,3-dienes for stereodivergent diels-alder reactions.

Nature communications·2026
Same author

Base-Promoted Conversion of Propargylic Alcohols to 1,3-Enynes.

Organic letters·2026
Same author

Total Synthesis of (+)-Melonine and (+)-N<sub>4</sub>-Oxy Melonine Enabled by an Intramolecular Alkene Diamination Reaction.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Mar 26, 2026

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
09:36

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Published on: March 8, 2024

1.6K

Total Synthesis of (±)-Strictamine.

Weiwu Ren1, Qian Wang1, Jieping Zhu2

  • 1Laboratory of Synthesis and Natural Products, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, BCH 5304, 1015, Lausanne, Switzerland.

Angewandte Chemie (International Ed. in English)
|February 5, 2016
PubMed
Summary

The total synthesis of strictamine was achieved in nine steps. Key innovations include creating a quaternary stereocenter and constructing the bicyclic core using a tertiary amine surrogate.

Keywords:
alkaloidscyclizationheterocyclesnatural productstotal synthesis

More Related Videos

Synthesis and Structure Determination of &#181;-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

13.3K
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

11.2K

Related Experiment Videos

Last Updated: Mar 26, 2026

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
09:36

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques

Published on: March 8, 2024

1.6K
Synthesis and Structure Determination of &#181;-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
11:44

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities

Published on: October 2, 2018

13.3K
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

11.2K

Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry

Background:

  • Strictamine is a complex natural product with a challenging molecular structure.
  • Previous synthetic routes to strictamine and its analogs have been limited.

Purpose of the Study:

  • To develop an efficient and concise total synthesis of strictamine.
  • To establish a novel synthetic strategy for constructing the strictamine core.

Main Methods:

  • Total synthesis of strictamine in nine steps starting from an enol triflate.
  • Formation of a C7 all-carbon quaternary stereocenter.
  • Utilized an N,N-dimethyl tertiary amine as a primary amine surrogate for building the 2-azabicyclo[3,3,1]nonan-9-one skeleton.
  • Employed alpha-bromination of a ketone followed by stereoconvergent intramolecular nucleophilic substitution.
  • Late-stage construction of the indolenine moiety.

Main Results:

  • Successful nine-step total synthesis of strictamine.
  • Efficient creation of a challenging C7 quaternary stereocenter.
  • Demonstrated a novel method for constructing the bicyclic core using a tertiary amine surrogate.
  • Achieved late-stage indolenine formation.

Conclusions:

  • The developed synthetic route provides an efficient access to strictamine.
  • The strategy highlights the utility of tertiary amines as surrogates in complex molecule synthesis.
  • This work lays the foundation for synthesizing strictamine analogs.