Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

4.2K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
4.2K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.9K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.9K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.8K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

86.0K
Overview
86.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.2K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.2K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.5K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epitope-selective vaccine designs to elicit protective antibodies against the Plasmodium falciparum circumsporozoite protein.

NPJ vaccines·2026
Same author

Relevance of the antibody Fc fragment and epitope valency in protection against malaria sporozoites.

EMBO reports·2026
Same author

Conserved but mechanistically diverse piRNA defence against endogenous retroviruses in insects.

EMBO reports·2026
Same author

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

γδ T cell-derived IL-4 initiates CD8<sup>+</sup> T cell immunity.

Nature immunology·2026
Same author

Liver sinusoid constraints make random search of CD8 T cells for Plasmodium parasites efficient.

bioRxiv : the preprint server for biology·2025
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.5K

Dendritic cell function and antigen presentation in malaria.

Ian A Cockburn1, Fidel Zavala2

  • 1Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.

Current Opinion in Immunology
|February 5, 2016
PubMed
Summary
This summary is machine-generated.

Understanding how malaria antigens are presented to T cells is crucial for developing effective vaccines and treatments. Research shows Plasmodium antigen presentation by endothelial cells contributes to malaria pathogenesis, particularly cerebral malaria.

More Related Videos

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

21.5K
Evaluation of Extracellular Vesicle Function During Malaria Infection
13:45

Evaluation of Extracellular Vesicle Function During Malaria Infection

Published on: February 14, 2018

8.1K

Related Experiment Videos

Last Updated: Mar 26, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.5K
Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

21.5K
Evaluation of Extracellular Vesicle Function During Malaria Infection
13:45

Evaluation of Extracellular Vesicle Function During Malaria Infection

Published on: February 14, 2018

8.1K

Area of Science:

  • Immunology
  • Infectious Diseases
  • Malariology

Background:

  • T cells are vital in malaria immunity and disease.
  • Antigen presentation by various cells influences T cell responses.
  • Cerebral malaria involves T cell pathology and dendritic cell dysfunction.

Purpose of the Study:

  • To elucidate antigen-presenting cells and antigens in malaria.
  • To understand T cell roles in pre-erythrocytic and blood stages of malaria.
  • To investigate the role of endothelial cells in malaria pathogenesis.

Main Methods:

  • Advanced imaging techniques to study antigen presentation.
  • Analysis of T cell responses during different malaria infection stages.
  • Investigation of dendritic cell function and T cell interactions.

Main Results:

  • Plasmodium antigen presentation during T cell priming and effector phases identified.
  • Endothelial cells presenting malaria antigens are key in pathogenesis.
  • Dendritic cell dysfunction and pathogenic T cells contribute to brain pathology.

Conclusions:

  • Identifying antigen-presenting cells is critical for malaria control.
  • Endothelial cell antigen presentation is a significant factor in malaria pathology.
  • Targeting these T cell-mediated processes could lead to new therapies and vaccines.