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Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
[CLINICAL SIGNIFICANCE OF NONCODING RNA IN HEPATOCELLULAR CARCINOMA]
Abstract:
RNAs lacking protein-coding ability are called "noncoding RNAs" (ncRNAs). ncRNAs include microRNA (19-24 nucleotides in length) and long ncRNA (lncRNA). MicroRNA binds to the 3'-untranslated regions of target mRNAs and regulates target genes at a posttranscriptional level. In hepatocellular carcinoma (HCC), the roles of microRNAs in hepatocarcinogenesis and microRNAs that can determine the nature of HCC have been reported. Because microRNA is stable in the bloodstream or formalin-fixed specimens, it can be used as a tumor marker. MicroRNAs as therapeutic targets for HCC are being intensively investigated. A phase I clinical study using miR-34 is currently in progress. On the other hand, the investigation of lncRNAs has only recently begun. Because lncRNAs are also involved in hepatocarcinogenesis and can determine the nature of cancers, many researchers are now working on these RNAs.
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lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
Types of RNA
RNA Performs Diverse...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Cell Specific Gene Expression
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