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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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New Management Strategies in Heart Failure
Anjali Tiku Owens1, Susan C Brozena1, Mariell Jessup2
1From the Cardiovascular Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.
Circulation Research
|February 6, 2016
Summary
Recent advancements offer new hope for chronic heart failure patients. Two new drugs, ivabradine and sacubitril/valsartan, approved in 2015, target heart failure with reduced ejection fraction.
Area of Science:
- Cardiology
- Pharmacology
- Translational Medicine
Background:
- Chronic heart failure treatment saw limited new drug approvals between 2005 and 2015.
- Existing therapies offered modest improvements for a condition with a poor prognosis.
Purpose of the Study:
- To review recent advancements in heart failure pharmacotherapy.
- To highlight newly approved drugs and emerging treatment strategies for heart failure.
Main Methods:
- Review of clinical trial data and regulatory approvals.
- Synthesis of research on novel therapeutic mechanisms in heart failure.
Main Results:
- The US Food and Drug Administration approved two new drugs in 2015: ivabradine and sacubitril/valsartan (LCZ696).
- These novel therapies target chronic heart failure with reduced ejection fraction, offering new physiological approaches.
Conclusions:
- Recent drug approvals signal a paradigm shift in heart failure management.
- Ongoing research explores innovative strategies for various stages of the heart failure syndrome.
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