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Euglycemic hyperinsulinemia increases glucose 1,6-bisphosphate in human skeletal muscle
A Katz1, B L Nyomba, C Bogardus
1Clinical Diabetes and Nutrition Section, National Institute of Diabetes, Digestive and Kidney Diseases, Phoenix, AZ 85016.
The International Journal of Biochemistry
|January 1, 1989
Abstract:
1. The effects of physiologic concentrations of insulin on the contents of glucose 1,6-bisphosphate (glucose 1,6-P2) and regulators of glucose 1,6-P2 synthase in intact human skeletal muscle have been investigated. 2. Insulin increased glucose 1,6-P2 from a basal value of 70 +/- 6 to 135 +/- 12 mumol/kg dry wt (P less than 0.001). 3. Activation of synthase could not be associated with changes in its inhibitors (fructose 1,6-P2, Pi, citrate) or its substrate glucose 6-P.