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Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Collagens are the Major Structural Proteins of ECM01:13

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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
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Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
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Structural Protein Function01:56

Structural Protein Function

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
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Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

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Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
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Matrix Proteoglycans and Glycoproteins01:21

Matrix Proteoglycans and Glycoproteins

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Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
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Related Experiment Video

Updated: Mar 26, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

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Collagen binding to OSCAR: the odd couple.

Bo An1, Barbara Brodsky1

  • 1TUFTS UNIVERSITY.

Blood
|February 6, 2016
PubMed
Summary

Researchers revealed the structure of the collagen-activated osteoclast-associated receptor (OSCAR) interacting with collagen. This discovery uncovers a new way immunoglobulin-like motifs recognize collagen, advancing our understanding of molecular interactions.

Area of Science:

  • Structural biology
  • Immunology
  • Biochemistry

Background:

  • Osteoclast-associated receptor (OSCAR) plays a role in bone metabolism and immune responses.
  • Collagen is a major structural protein involved in various biological processes.
  • Understanding receptor-ligand interactions is crucial for deciphering cellular signaling.

Purpose of the Study:

  • To determine the high-resolution structure of OSCAR bound to a collagen model peptide.
  • To elucidate the molecular mechanism by which OSCAR recognizes collagen.

Main Methods:

  • X-ray crystallography was used to obtain the high-resolution structure.
  • Biochemical binding studies were performed to analyze the interaction.

Main Results:

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Related Experiment Videos

Last Updated: Mar 26, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides

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Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction
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  • The study reports the high-resolution crystal structure of OSCAR complexed with a collagen model peptide.
  • The structure reveals specific interactions between OSCAR's immunoglobulin-like motifs and the collagen peptide.
  • Binding studies corroborate the structural findings, confirming the interaction mode.

Conclusions:

  • A novel collagen recognition mechanism mediated by immunoglobulin-like motifs in OSCAR has been identified.
  • This finding provides new insights into the molecular basis of collagen-OSCAR interaction.
  • The results contribute to the understanding of OSCAR function in biological contexts.