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Related Experiment Videos

[Cathinones use in Paris].

A Batisse1, M Grégoire2, M Marillier1

  • 1CEIP-Addictovigilance, hôpital Fernand-Widal, 200, rue du Faubourg-Saint-Denis, 75010 Paris cedex 10, France.

L'Encephale
|February 6, 2016
PubMed
Summary
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COgnitive enhancement and consumption of psychoactive Substances among Youth Students (COSYS): a cross-sectional study in France.

Public health·2021

New psychoactive substances (NPS), like synthetic cathinones, are increasingly abused, particularly in France. The "slam" phenomenon, involving injection drug use, sexual parties, and psychostimulants, is prevalent among men who have sex with men (MSM).

Area of Science:

  • Pharmacology
  • Toxicology
  • Public Health

Background:

  • Recreational drug use has evolved to include new psychoactive substances (NPS), such as synthetic cathinones, which emerged in France in 2008.
  • Despite legal bans in France since 2012, synthetic cathinones remain accessible online and widely used, with the Paris Addictovigilance Centre reporting 21 abuse cases over two years.

Purpose of the Study:

  • To describe cathinone use patterns in the Paris area.
  • To alert healthcare professionals to the challenges in identifying and assessing the risks associated with these compounds.
  • To provide clinicians with guidance on clinical presentation and treatment modalities for cathinone abuse.

Main Methods:

  • Review of chemical structure, pharmacology, and toxicology of derivated cathinones.
Keywords:
AddictionDrogues de synthèseDrugs of synthesisPharmacopsychoseSexualitySexualité

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  • Clinical observation and case reporting from the Paris Addictovigilance Centre.
  • Analysis of user-reported behaviors and associated health risks.

    • Main Results:

    • Synthetic cathinone users commonly experience euphoria, increased energy, and heightened sexual arousal.
    • Toxicity signs align with a sympathomimetic toxidrome, with psychiatric issues (psychosis, agitation) and addiction being primary reasons for seeking care.
    • The 'slam' phenomenon, characterized by injection drug use at sexual parties, is noted among men who have sex with men (MSM), increasing infectious risks (HIV, VHC, VHB).
    • Cathinones are not detected by standard drug screenings, necessitating specialized analyses (GC/LC-MS) for accurate identification.

    Conclusions:

    • Cathinones are used to enhance sexual experience and are associated with the 'slam' phenomenon, particularly in MSM populations.
    • Rapid dependence, prolonged psychiatric symptoms, and increased infectious disease transmission are significant risks.
    • Harm reduction strategies must include targeted interventions for MSM within sexual and drug addiction networks.