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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Non-Coding RNAs in Thyroid Cancer.

Ranran Zhang1, Heather Hardin1, Jidong Chen1

  • 1Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, 53792, USA.

Endocrine Pathology
|February 6, 2016
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play roles in thyroid cancer. Their deregulation shows potential for diagnosing and predicting thyroid tumors.

Keywords:
In situ hybridizationMicroRNANon-coding RNAThyroidThyroid carcinomalncRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs) are crucial regulators of gene expression.
  • ncRNAs are broadly classified into small ncRNAs (e.g., microRNAs) and long ncRNAs (lncRNAs).
  • Dysregulation of ncRNAs is implicated in various pathologies, including cancer.

Purpose of the Study:

  • To review recent advancements in understanding the role of ncRNAs in thyroid cancer development.
  • To explore the potential diagnostic and prognostic applications of ncRNAs in thyroid tumors.

Main Methods:

  • Literature review of studies on ncRNAs in thyroid tissues.
  • Analysis of current research on microRNA and lncRNA involvement in thyroid tumorigenesis.
  • Discussion of detection methods and challenges for ncRNAs in pathology.

Main Results:

  • MicroRNA deregulation is increasingly recognized as a potential biomarker in thyroid pathology.
  • Research into the role of lncRNAs in thyroid cancer is rapidly evolving.
  • ncRNAs offer novel avenues for thyroid cancer diagnosis and prognosis.

Conclusions:

  • ncRNAs, particularly miRNAs and lncRNAs, are significantly involved in thyroid cancer.
  • Further research into ncRNAs could lead to improved diagnostic and prognostic tools for thyroid tumors.
  • ncRNAs represent a promising area for future thyroid cancer research and clinical application.