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MicroRNA expression pattern in pre-eclampsia (Review).

Deeba S Jairajpuri1, Wassim Y Almawi1

  • 1Department of Medical Biochemistry, Arabian Gulf University, Manama 26671, Kingdom of Bahrain.

Molecular Medicine Reports
|February 6, 2016
PubMed
Summary

This review explores microRNAs as potential early diagnostic markers for pre-eclampsia (PE), a serious pregnancy complication. Aberrant placental microRNA expression, detectable in blood, may offer new insights into PE pathogenesis and clinical assessment.

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Area of Science:

  • Reproductive Medicine
  • Molecular Biology
  • Genetics

Background:

  • Pre-eclampsia (PE) is a significant cause of maternal and fetal complications, with unclear etiology.
  • Current diagnostic methods for PE lack early predictive markers, appearing only mid-gestation.
  • MicroRNAs are key gene regulators implicated in various pathologies, including pregnancy complications.

Purpose of the Study:

  • To review current research on the association between placental microRNAs and pre-eclampsia.
  • To discuss the potential of microRNAs as minimally invasive biomarkers for PE onset and progression.
  • To explore the role of microRNA-target gene interactions in PE pathogenesis.

Main Methods:

  • Literature review of studies investigating microRNA expression in pre-eclampsia.
  • Analysis of findings on placental microRNAs detectable in maternal blood.
  • Discussion of mechanisms underlying microRNA involvement in PE.

Main Results:

  • Growing evidence links aberrant expression of placental microRNAs to pre-eclampsia.
  • Specific microRNAs found in blood show potential as circulating biomarkers for PE.
  • MicroRNA-target gene interactions are crucial in the pathogenesis of PE.

Conclusions:

  • Placental microRNAs, particularly those in circulation, represent promising candidates for early PE detection.
  • Further research is needed to clarify the clinical utility and specific roles of microRNAs in PE.
  • Understanding microRNA dysregulation can advance PE diagnostics and therapeutics.