[Long-term side effects of successful anti-tumor therapy. 2: Effects on fertility and bone marrow function; risk of...

Although long-term adverse effects can also manifest as a persistence of acute adverse reactions, true late sequelae of prior treatment often occur like a "bolt from the blue", as it were. In Part I of this paper, long-term adverse reactions affecting the skin, blood vessels, nerves were described. In the second part of this paper, the adverse effects on fertility are discussed, with attention being paid to mutagenicity, the rate of anomalies and miscarriages, and disorders of bone marrow function. Finally, the question as to secondary malignant disease, in particular the risk of secondary leukemia, is considered.