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Updated: Mar 26, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients
Jonathan Watt1, Simon Kennedy2, Nadeem Ahmed2
1West of Scotland Regional Heart & Lung Centre, Golden Jubilee National Hospital , Glasgow , UK.
Insights
Oxidized low-density lipoprotein (oxLDL) is linked to more endothelial progenitor cells (EPCs) in coronary heart disease (CHD) patients, suggesting a repair response. Lower EPCs correlate with endothelial dysfunction in stable CHD.
Area of Science:
- Cardiovascular Research
- Atherosclerosis Pathogenesis
- Endothelial Biology
Background:
- Coronary endothelial dysfunction and repair involve circulating factors.
- Oxidized low-density lipoprotein (oxLDL) and endothelial progenitor cells (EPCs) are implicated in cardiovascular health.
Purpose of the Study:
- To investigate the relationship between oxLDL, circulating EPCs, and coronary endothelial function in stable coronary heart disease (CHD).
Main Methods:
- Studied 33 patients with stable CHD.
- Measured plasma oxLDL using ELISA.
- Assessed coronary endothelial function via intracoronary acetylcholine infusion.
- Quantified EPCs (CD34+/KDR+) using flow cytometry.
Main Results:
- Plasma oxLDL positively correlated with circulating EPCs (r=0.46, p=0.02).
- Circulating EPCs positively correlated with coronary endothelial function (r=0.42, p=0.04).
- No significant correlation found between oxLDL and coronary endothelial function.
Conclusions:
- Elevated oxLDL in CHD patients is associated with increased EPCs, potentially indicating a repair mechanism.
- Coronary endothelial dysfunction in stable CHD is linked to reduced circulating EPCs, suggesting a role in atherosclerosis development.
Objective:
The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD).
Methods:
33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells.
Results:
Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function.
Conclusions:
Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis.
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