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Drivers of MERS-CoV transmission: what do we know?

Jaffar A Al-Tawfiq1,2, Ziad A Memish3,4

  • 1a Medical Department , Johns Hopkins Aramco Healthcare , Dhahran , Saudi Arabia.

Expert Review of Respiratory Medicine
|February 6, 2016
PubMed

Insights

Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes varied illness and spreads through families and healthcare settings. Viral, host, and environmental factors drive MERS-CoV transmission, requiring further study.

Area of Science:

  • * Infectious Diseases
  • * Virology
  • * Epidemiology

Background:

  • * Middle East Respiratory Syndrome coronavirus (MERS-CoV) emerged in 2012.
  • * It causes a spectrum of illness, from asymptomatic to fatal cases.
  • * Transmission occurs sporadically, within families, and notably in healthcare settings.

Purpose of the Study:

  • * To summarize known factors contributing to MERS-CoV transmission.
  • * To highlight the diverse transmission patterns observed.
  • * To identify key elements facilitating spread in healthcare environments.

Main Methods:

  • * Systematic review of existing literature on MERS-CoV transmission.
  • * Analysis of reported cases and outbreak investigations.
  • * Synthesis of data on viral, host, and environmental factors.

Main Results:

  • * Healthcare-associated transmissions are linked to overcrowding, poor infection control, unrecognized cases, superspreading events, and inadequate triage.
  • * MERS-CoV transmission is influenced by a complex interplay of viral characteristics, host susceptibility, and environmental conditions.
  • * The precise contributing factors to MERS-CoV spread require ongoing systematic investigation.

Conclusions:

  • * Understanding the multifaceted factors influencing MERS-CoV transmission is crucial for effective control.
  • * Addressing healthcare-associated risks is paramount in mitigating outbreaks.
  • * Further research is needed to fully elucidate the drivers of MERS-CoV's diverse transmission dynamics.
Keywords:
CoronavirusHealth Care FacilitiesMERS-CoVPreventionTransmission

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