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Essential hypertension and histocompatibility antigens. A linkage study
M Gerbase-DeLima1, J J DeLima, L B Persoli
1Escola Paulista de Medicina, Universidade de São Paulo, Brazil.
Hypertension (Dallas, Tex. : 1979)
|December 1, 1989
Summary
Genetic factors influence essential hypertension. This study found evidence suggesting genes predisposing to high blood pressure are located near or within the human leukocyte antigen (HLA) complex, a finding that requires further investigation.
Area of Science:
- Genetics
- Immunology
- Cardiovascular Disease
Background:
- Essential hypertension has complex genetic and environmental origins.
- Previous studies on the association between human leukocyte antigen (HLA) genes and essential hypertension have yielded inconsistent results.
- The role of the HLA complex in hypertension susceptibility remains controversial.
Purpose of the Study:
- To investigate the potential linkage of genes predisposing to essential hypertension within or near the HLA complex.
- To clarify the controversial role of HLA in the genetic etiology of essential hypertension.
Main Methods:
- Linkage analysis was employed in the study.
- Data were collected from 96 hypertensive siblings across 31 families.
- Segregation patterns of HLA haplotypes were analyzed.
Main Results:
- A significant distortion in the normal segregation pattern of HLA haplotype inheritance was observed (p = 0.0009).
- This distortion suggests a genetic linkage between HLA and essential hypertension.
Conclusions:
- The findings indicate that at least one gene contributing to the genetic predisposition of essential hypertension is located very close to or within the HLA complex.
- This study provides evidence supporting the role of the HLA region in the genetic basis of essential hypertension.