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Bowen's disease and internal malignancy. A meta-analysis
1Department of Dermatology, University of Minnesota School of Medicine, Minneapolis.
International Journal of Dermatology
|October 1, 1989
Summary
This meta-analysis found no significant association between Bowen's disease and internal malignancy. Extensive investigations are not warranted for patients diagnosed with Bowen's disease.
Area of Science:
- Dermatology
- Oncology
Background:
- Bowen's disease, a form of squamous cell carcinoma in situ, has been controversially linked to internal malignancies.
- Previous studies have yielded conflicting results regarding this association.
Purpose of the Study:
- To critically evaluate the association between Bowen's disease and internal malignancy using a meta-analysis approach.
- To provide a statistically robust conclusion on the potential link between these two conditions.
Main Methods:
- A meta-analysis was conducted, pooling data from 12 English-language studies.
- Statistical analysis, including chi-square testing, was employed to assess the significance of the association.
Main Results:
- The meta-analysis revealed no statistically significant association between Bowen's disease and internal malignancy (p > 0.05).
- The calculated confidence interval further supports the lack of a meaningful link.
Conclusions:
- The findings suggest that a diagnosis of Bowen's disease does not warrant extensive investigation for concurrent internal malignancy.
- This study clarifies a long-standing controversy in dermatological and oncological literature.