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Related Experiment Video

Updated: Mar 26, 2026

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More compression improves sealing effect on larger pulmonary arteries.

Andreas Kirschbaum1, Franziska Rüdell1, Anika Pehl2

  • 1Department of Visceral, Thoracic and Vascular Surgery, Giessen and Marburg University Hospital (UKGM), Marburg, Germany.

The Journal of Surgical Research
|February 7, 2016
PubMed
Summary

Higher compression force and a 5-second delay in bipolar sealing significantly improve bursting pressures in pulmonary arteries larger than 7 mm. This optimization enhances vessel sealing safety for larger diameter vessels.

Keywords:
Bipolar blood vessel sealingBursting pressureCompression durationCompression forceMARSEALPulmonary arterySealSafe

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Area of Science:

  • Vascular surgery
  • Surgical instrumentation
  • Biomedical engineering

Background:

  • Bipolar sealing instruments effectively seal vessels up to 7 mm.
  • Previous methods showed unsatisfactory results for sealing larger vessels (>7 mm).
  • Optimization of sealing parameters is needed for larger diameter vessels.

Purpose of the Study:

  • To investigate if increased compression force and duration improve bursting pressures in pulmonary arteries >7 mm.
  • To evaluate the efficacy of the MARSEAL instrument with SealSafe G3 for larger vessels.
  • To determine optimal compression parameters for safe vessel sealing.

Main Methods:

  • Ex vivo porcine pulmonary artery model used.
  • Vessels categorized into three diameter groups: 1-6 mm, 7-12 mm, and >12 mm.
  • MARSEAL instruments tested with varying compression forces (35 N, 45 N, 55 N) and durations (0 s, 5 s, 10 s, 20 s).
  • Bursting pressures measured via pneumatic testing; statistical analysis using Mann-Whitney U test.

Main Results:

  • For vessels >7 mm, 55 N compression yielded significantly higher mean bursting pressures compared to lower forces.
  • A 5-second compression delay significantly increased mean bursting pressures versus no delay.
  • Compression durations beyond 5 seconds did not provide further significant increases in bursting pressure.
  • Histological examination showed no differences related to compression force.

Conclusions:

  • Higher compression force (55 N) achieves satisfactory bursting pressures for pulmonary arteries >7 mm.
  • A 5-second compression delay before coagulation significantly enhances sealing security.
  • Extended compression times offer no additional benefit for vessel sealing.