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Related Experiment Video

Updated: Mar 26, 2026

Creation of Abdominal Adhesions in Mice
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Ghrelin ameliorates adhesions in a postsurgical mouse model.

Enrica Bianchi1, Kim Boekelheide2, Mark Sigman1

  • 1Department of Surgery, Division of Urology, Brown University, Providence, Rhode Island; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island.

The Journal of Surgical Research
|February 7, 2016
PubMed
Summary

Ghrelin administration significantly reduced postoperative peritoneal adhesions in a novel mouse model. This effect, mediated by the ghrelin receptor, suggests ghrelin may improve surgical outcomes by reducing fibrotic responses.

Keywords:
Collagen IFibrosisGHSR-1a receptorGhrelinPostoperative adhesion

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Area of Science:

  • Surgical innovation and molecular biology.
  • Gastroenterology and regenerative medicine.

Background:

  • Peritoneal adhesions are a common surgical complication, leading to infertility, pain, and obstruction.
  • Ghrelin, a stomach-derived peptide, was hypothesized to play a role in preventing these adhesions.

Purpose of the Study:

  • To develop a novel mouse model for studying peritoneal adhesion formation.
  • To define the role of ghrelin in wound healing and adhesion development post-surgery.

Main Methods:

  • A new peritoneal adhesion model was created in wild-type and growth hormone secretagogue receptor-knockout (GHSR KO) mice.
  • Mice received ghrelin or saline injections, and collagen levels were analyzed to assess fibrotic response.

Main Results:

  • The developed mouse model consistently produced intra-abdominal adhesions.
  • Ghrelin significantly reduced adhesion formation and collagen levels in wild-type mice.
  • This anti-adhesion effect was absent in GHSR KO mice, confirming mediation by the GHSR-1a receptor.

Conclusions:

  • Ghrelin administration shows potential in reducing peritoneal adhesions and fibrotic responses.
  • Ghrelin may improve surgical outcomes by mitigating postoperative adhesion formation.