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[DOhaD and epigenetic information: societal challenges].

Emmanuelle Rial-Sebbag1, Caroline Guibet Lafaye2, Umberto Simeoni3

  • 1Inserm UMR 1027, université Toulouse III Paul Sabatier, faculté de médecine, 37, allées Jules Guesde, 31062 Toulouse Cedex, France.

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Summary

The developmental origins of health and disease (DOHaD) paradigm shifts understanding of chronic diseases. Epigenetic insights from DOHaD research necessitate multidisciplinary approaches to address future societal and ethical questions.

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Area of Science:

  • Public Health
  • Developmental Biology
  • Epigenetics

Background:

  • The developmental origins of health and disease (DOHaD) concept reframes understanding of chronic, non-communicable diseases.
  • DOHaD influences health and disease development across the lifespan, particularly in high-income and emerging economies.
  • This paradigm shift impacts various scientific disciplines, including psychological, social, economic, ethical, and legal sciences.

Purpose of the Study:

  • To explore the societal implications of DOHaD research, particularly concerning epigenetic mechanisms.
  • To highlight the unforeseen nature of knowledge gained from epigenetics and lifestyle factors during development.
  • To emphasize the need for a pluridisciplinary approach to anticipate and address future societal and ethical questions arising from DOHaD.

Main Methods:

  • Conceptual analysis of the DOHaD paradigm.
  • Review of epigenetic mechanisms and their link to lifestyle.
  • Exploration of potential societal, ethical, and legal implications.

Main Results:

  • DOHaD research necessitates a paradigm shift in understanding health and disease.
  • Epigenetic mechanisms and developmental lifestyle factors present unforeseen societal challenges.
  • Anticipating future issues requires early, multidisciplinary engagement.

Conclusions:

  • The DOHaD concept provides a basis for global prevention policies.
  • Epigenetic discoveries linked to DOHaD raise complex societal and ethical questions.
  • Proactive, pluridisciplinary research and reflection are crucial for navigating the implications of DOHaD and epigenetics.