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Related Concept Videos

Hypoxia01:23

Hypoxia

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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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General Transcription Factors01:30

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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Exploiting the hypoxia sensitive non-coding genome for organ-specific physiologic reprogramming.

Corinne Bischof1, Jaya Krishnan1

  • 1MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom; Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe-University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Biochimica Et Biophysica Acta
|February 7, 2016
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs play a key role in heart disease development. Targeting these RNAs, particularly under hypoxia via HIF1α, offers potential therapeutic strategies for cardiac pathology.

Keywords:
CardiomyopathyHypoxiaNon-coding RNA

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • RNA Therapeutics

Background:

  • Cardiac pathology involves complex molecular changes.
  • Hypoxia is a significant driver of heart disease progression.
  • Non-coding RNAs (ncRNAs) are increasingly recognized in disease pathogenesis.

Purpose of the Study:

  • To review the role of ncRNAs in cardiac pathology.
  • To explore hypoxia-inducible factor 1α (HIF1α) mediated regulation of ncRNAs in heart disease.
  • To identify ncRNAs as potential therapeutic targets for cardiac conditions.

Main Methods:

  • Literature review focusing on ncRNAs and cardiac pathology.
  • Analysis of HIF1α's role in regulating the non-coding transcriptome.
  • Examination of metabolic, growth, and functional reprogramming in cardiac disease.

Main Results:

  • Hypoxia, via HIF1α, significantly influences the non-coding transcriptome in the heart.
  • HIF1α-regulated ncRNAs contribute to metabolic, growth, and functional reprogramming in cardiac pathology.
  • Specific ncRNAs are implicated in the establishment and progression of cardiac disease states.

Conclusions:

  • Non-coding RNAs are critical mediators in the development and progression of cardiac pathology.
  • Targeting HIF1α-regulated ncRNAs presents a promising avenue for novel cardiac therapeutics.
  • Understanding the interplay between HIF1α and the non-coding transcriptome is key for clinical translation.