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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Pruning Cancer's Evolutionary Tree with Lesion-Directed Therapy.

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Next-generation sequencing of tumor biopsies and circulating tumor DNA helps guide colorectal cancer treatment by monitoring tumor evolution and acquired resistance.

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Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) is a significant global health concern.
  • Tumor evolution and acquired resistance are major challenges in effective CRC treatment.
  • Personalized therapeutic strategies are crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the utility of next-generation sequencing (NGS) for monitoring colorectal cancer.
  • To assess the role of spatially and temporally separated biopsies and circulating tumor DNA (ctDNA) in guiding therapy.
  • To understand tumor evolution and mechanisms of acquired resistance in CRC.

Main Methods:

  • Employing next-generation sequencing on serial biopsies and ctDNA from colorectal cancer patients.
  • Analyzing genomic alterations to track tumor heterogeneity and clonal evolution.
  • Correlating molecular findings with treatment response and clinical outcomes.

Main Results:

  • NGS of ctDNA and biopsies revealed dynamic changes in tumorS during treatment.
  • Specific genetic alterations associated with acquired resistance were identified.
  • Therapeutic decisions were successfully adjusted based on molecular profiling.

Conclusions:

  • Spatially and temporally separated biopsies and ctDNA analysis are valuable tools for monitoring CRC.
  • This approach enables timely adjustments to therapy in response to tumor evolution and resistance.
  • Personalized treatment strategies guided by molecular insights can improve CRC management.