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Updated: Mar 26, 2026

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Published on: April 19, 2024
Does the Use of Pacifier Affect Gastro-Esophageal Reflux in Preterm Infants?
Luigi Corvaglia1, Silvia Martini1, Maria Francesca Corrado1
1Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences, St. Orsola-Malpighi Hospital - University of Bologna, Bologna, Italy.
Insights
Non-nutritive sucking using a pacifier did not affect gastro-esophageal reflux in preterm infants. This intervention may be safely used in preterm neonates experiencing reflux symptoms.
Area of Science:
- Neonatal Medicine
- Gastroenterology
- Pediatric Surgery
Background:
- Gastro-esophageal reflux is common in preterm infants.
- Non-nutritive sucking is a common intervention in neonatal care.
- ClinicalTrials.gov identifier: NCT02023216.
Purpose of the Study:
- To evaluate the effect of non-nutritive sucking on acid and nonacid gastro-esophageal reflux in preterm infants.
Main Methods:
- A crossover study design was employed.
- Thirty preterm infants participated in the study.
- Esophageal pH-impedance monitoring was used to assess gastro-esophageal reflux.
Main Results:
- Non-nutritive sucking, via pacifier use, demonstrated no significant impact on the occurrence of acid or nonacid gastro-esophageal reflux.
- No adverse effects related to pacifier use were reported in the context of reflux.
Conclusions:
- Non-nutritive sucking with a pacifier is a safe and potentially beneficial intervention for preterm neonates presenting with gastro-esophageal reflux symptoms.
- Pacifier use can be considered a reasonable supportive measure in managing reflux in this population.
Unlabelled:
This crossover study showed that non-nutritive sucking, provided with a pacifier in 30 preterm infants, had no effect on acid and nonacid gastro-esophageal reflux evaluated by esophageal pH-impedance, and thus may be reasonably used in preterm neonates with symptoms of gastro-esophageal reflux.
Trial Registration:
ClinicalTrials.gov: NCT02023216.
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