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Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses
Published on: June 7, 2018
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Phase behavior, intermolecular interaction, and solid state characterization of amorphous solid dispersion of
Ashwini Kini1, Sarsvatkumar B Patel1
1a Department of Pharmaceutics , Long Island University , Brooklyn , NY , USA.
Pharmaceutical Development and Technology
|February 9, 2016
Summary
This study prepared amorphous molecular dispersions of Febuxostat (FXT) with polymers, analyzing their physical properties and glass transition temperature (Tg) using mathematical models to understand drug-polymer interactions and mixing states.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Amorphous solid dispersions enhance drug solubility and bioavailability.
- Febuxostat (FXT) is a drug used to treat gout, but its amorphous form requires stabilization.
Purpose of the Study:
- To prepare and characterize amorphous molecular dispersions of Febuxostat (FXT) using various polymers.
- To analyze the physicochemical stability and intermolecular interactions within these dispersions using mathematical models.
Main Methods:
- Solid dispersions prepared via solvent evaporation technique.
- Characterization using differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FTIR).
- Glass transition temperature (Tg) data modeled using Gordon-Taylor, Couchman-Karasz, Brekner-Schneider-Cantow, and BCKV equations.
Main Results:
- Successful preparation of amorphous molecular dispersions of FXT with PVP K30, HPMC-AS, Soluplus®, and PVP VA64.
- Tg versus composition dependencies were analyzed and mathematically modeled.
- Intermolecular interactions and the state of mixing were assessed based on model parameters and thermal analysis.
Conclusions:
- The study provides insights into the physicochemical stability of FXT amorphous dispersions.
- Mathematical modeling of Tg effectively characterizes drug-polymer interactions and mixing states.
- Understanding these interactions is crucial for developing stable and effective amorphous solid dispersions.
Keywords:
Amorphous solid dispersionsdrug–polymer interactionsglass transitionhydrogen bondinginfrared spectroscopymiscibilityMore Related Videos
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