Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Autoantigens in autoimmune thyroid diseases].

T Kotani

    Rinsho Byori. the Japanese Journal of Clinical Pathology
    |August 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    This study demonstrates that human thyroid peroxidase (TPO) binds to autoantibodies in autoimmune thyroid diseases and induces thyroiditis in mice. Researchers also sequenced the full-length human TPO cDNA, revealing its primary amino acid structure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Real-world clinical outcomes of patients with disproportionate articular pain in rheumatoid arthritis: ANSWER cohort study.

    Scandinavian journal of rheumatology·2026
    Same author

    Effect of intravenous lidocaine on nociception level-directed management in robot-assisted laparoscopic radical prostatectomy: protocol for a single-centre, factorial-randomised controlled trial (VALINOR study).

    Anaesthesia reports·2025
    Same author

    Importance of the time sequence between measurement of the predictor and of the predicted outcome: Response.

    International journal of obstetric anesthesia·2024
    Same author

    Predictive performance of Shock Index for postpartum hemorrhage during cesarean delivery.

    International journal of obstetric anesthesia·2023
    Same author

    Changes in the blood level, efficacy, and safety of tacrolimus in pregnancy and the lactation period in patients with systemic lupus erythematosus.

    Lupus·2018
    Same author

    Efficacy of discontinuing risedronate for patients with systemic lupus erythematosus: a prospective study.

    Lupus·2018
    Same journal

    [The Role of Laboratory Medicine in Hematopoietic Stem Cell Transplantation "Echocardiogram"].

    Rinsho byori. The Japanese journal of clinical pathology·2019
    Same journal

    [The Significance of Pulmonary Function Testing Before and After Allogeneic Stem Cell Transplantation].

    Rinsho byori. The Japanese journal of clinical pathology·2019
    Same journal

    [Blood Transfusion Inspection].

    Rinsho byori. The Japanese journal of clinical pathology·2019
    Same journal

    [The Role of Clinical Laboratory Technicians at Bone Marrow Transplantation : Blood Test].

    Rinsho byori. The Japanese journal of clinical pathology·2019
    Same journal

    [The Foundation of Allogeneic Hematopoietic Stem Cell Transplantation and the Role of Clinical Laboratory Tests in This Field].

    Rinsho byori. The Japanese journal of clinical pathology·2019
    Same journal

    [How to Interpret Data from Routine Laboratory Tests].

    Rinsho byori. The Japanese journal of clinical pathology·2019
    See all related articles

    Area of Science:

    • Immunology
    • Molecular Biology
    • Endocrinology

    Context:

    • Autoimmune thyroid diseases (AITDs) involve immune system attacks on the thyroid gland.
    • Thyroid peroxidase (TPO) is a key autoantigen in AITDs, particularly Hashimoto's thyroiditis and Graves' disease.
    • Understanding TPO's structure and its interaction with autoantibodies is crucial for AITD pathogenesis.

    Purpose:

    • To investigate the binding characteristics of human thyroid peroxidase (TPO) with autoantibodies from patients with AITDs.
    • To explore the immunogenicity of TPO and its potential to induce experimental autoimmune thyroiditis (EAT) in animal models.
    • To determine the primary structure of human TPO by cloning and sequencing its complementary DNA (cDNA).

    Summary:

    • Human TPO was shown to bind IgG and IgM from AITD patients, with TPO inhibiting IgG binding to microsomes.

    Related Experiment Videos

  • Immunization of mice with porcine TPO induced thyroiditis in susceptible strains, suggesting TPO's role in autoimmune responses.
  • Cloning of human TPO cDNA from Graves' disease thyroid tissue yielded two variants, with the full-length cDNA comprising 3,048 nucleotides encoding 933 amino acids.

    • Impact:

    • This research provides insights into the molecular mechanisms underlying autoimmune thyroid diseases.
    • The characterization of human TPO and its immunogenic properties can aid in developing diagnostic tools and therapeutic strategies for AITDs.
    • Elucidating the primary structure of TPO is fundamental for future studies on its function and role in thyroid autoimmunity.